Reactor CR-1B

Product Overview

Reactor CR-1B (Fig. 1) is an automated chemical reactor with a thermostat, stirrer and reagent control system. A specialized software is used for reactor control (supplied with the reactor). This reactor can be of most interest in laboratory research for routine nano/microparticle syntheses (e.g. vaterite), as well as pilot-testing for scaling-up to further transfer it to production facilities.

Reagent Addition System

The reagent addition system is pneumatic (Fig. 2a). The flow of liquids inside the reactor is controlled by changing the pressure of an inert gas inside the chambers. The pneumatic reagent addition system is a distinctive feature of this reactor. This makes it possible to reduce the number of moving parts inside the reactor and minimize the dead volume at high rates of reagent addition.

Mechanical Stirrer

The mechanical stirrer with a hermetically sealed design (Fig. 2c). The stirrer drive motor is brushless, which ensures a long service life and high reliability of the device. The connection of the motor shaft to the rotor is direct, mechanical with a quick and easy release.

Single Replacement Unit

The block of containers for reagents is removable and can be quickly dismantled without the use of tools. This approach allows the reagent addition system and the reaction vessel, together with silicone tubes, to be an easily replaceable unit that can be quickly removed and replaced with another unit, eliminating cross-contamination when performing various chemical reactions by using Reactor CR-1B. Particles, e.g. vaterite (Fig. 3), can be easily obtained by the reactor with developed protocols that are integrated into the Reactor CR-1B software.

Features and details

Reactor flask capacity: 500 ml

Reactor temperature: up to 90°С

Agitator rotor speed: 200-2000 rpm

Number of channels for adding reagents: 2

Inert atmosphere inside the reactor: yes

Gas pressure inside the reactor: 0-0.5 bar

Rotator R1

Product Overview

Rotator R1 is a rotating mixer that allows to mix suspensions not only at room temperature but also at freezing temperatures (e.g. -20°C). For increased reliability and ease of use, a slip clutch is integrated inside the rotor.

Applications

Freezing temperature mixing can be used to carry out freezing-induced loading (FIL) of nanoparticles and high molecular weight compounds into submicron and micron porous particles with a complex structure and composition (Fig.2). Especially when coupled with Reactor CR-1B it can provide particles with high-reproducibility (Fig.3). At the same time, the device is versatile and can be used for mixing samples in laboratories at room temperature.

Easy and Safe

To increase the reliability of the device when operating at low temperatures (-20°C) and high humidity, the control unit is separated from the main body of the mixing device and is connected to it by a flexible cable. Thus, when using Rotator R1 in the freezer, the control unit remains outside the freezer and is not exposed to moisture and low temperatures. With this configuration, the freezer is supplied with a low current (200 mA) at 9V, which does not exceed the safety level. At the same time, the flexible flat cable is relatively narrow and does not create significant depressurization of the freezer unlike the standard cords.

Product-related publications

1. German, S. V.; Novoselova, M. V.; Bratashov, D. N.; Demina, P. A.; Atkin, V. S.; Voronin, D. V.; Khlebtsov, B. N.; Parakhonskiy, B. V.; Sukhorukov, G. B.; Gorin, D. A. High-Efficiency Freezing-Induced Loading of Inorganic Nanoparticles and Proteins into Micron- and Submicron-Sized Porous Particles. Sci. Rep. 2018, 8 (1), 17763.

2. Novoselova, M. V; German, S. V; Sindeeva, O. A.; Kulikov, O. A.; Minaeva, O. V; Brodovskaya, E. P.; Ageev, V. P.; Zharkov, M. N.; Pyataev, N. A.; Sukhorukov, G. B.; Gorin, D. A. Submicron-Sized Nanocomposite Magnetic-Sensitive Carriers: Controllable Organ Distribution and Biological Effects. Polymers (Basel). 2019, 11 (6), 1082.

3. Novoselova, M. V.; Voronin, D. V.; Abakumova, T. O.; Demina, P. A.; Petrov, A. V.; Petrov, V. V.; Zatsepin, T. S.; Sukhorukov, G. B.; Gorin, D. A. Focused Ultrasound-Mediated Fluorescence of Composite Microcapsules Loaded with Magnetite Nanoparticles: In Vitro and in Vivo Study. Colloids Surfaces B Biointerfaces 2019, 181 (June), 680–687.

4. Vostrikova, A. M.; Kokorina, A. A.; Demina, P. A.; German, S. V.; Novoselova, M. V.; Tarakina, N. V.; Sukhorukov, G. B.; Goryacheva, I. Y. Fabrication and Photoluminescent Properties of Tb3+ Doped Carbon Nanodots. Sci. Rep. 2018, 8 (1), 16301.

5. Mokrousov, M. D.; Novoselova, M. V.; Nolan, J.; Harrington, W.; Rudakovskaya, P.; Bratashov, D. N.; Galanzha, E. I.; Fuenzalida-Werner, J. P.; Yakimov, B. P.; Nazarikov, G.; Drachev, V. P.; Shirshin, E. A.; Ntziachristos, V.; Stiel, A. C.; Zharov, V. P.; Gorin, D. A. Amplification of Photoacoustic Effect in Bimodal Polymer Particles by Self-Quenching of Indocyanine Green. Biomed. Opt. Express 2019, 10 (9), 4775.

6. Kozlova, A. A.; German, S. V.; Atkin, V. S.; Zyev, V. V.; Astle, M. A.; Bratashov, D. N.; Svenskaya, Y. I.; Gorin, D. A. Magnetic Composite Submicron Carriers with Structure-Dependent MRI Contrast. Inorganics 2020, 8 (2), 11.

7. Demina, P. A.; Voronin, D. V.; Lengert, E. V.; Abramova, A. M.; Atkin, V. S.; Nabatov, B. V.; Semenov, A. P.; Shchukin, D. G.; Bukreeva, T. V. Freezing-Induced Loading of TiO2 into Porous Vaterite Microparticles: Preparation of CaCO3/TiO2 Composites as Templates to Assemble UV-Responsive Microcapsules for Wastewater Treatment. ACS Omega 2020, 5 (8), 4115–4124.

8. German S.V., Budylin G.S., E.A. Shirshin E.A., Gorin D.A. Advanced Technique for in situ Raman Spectroscopy Monitoring the Freezing-Induced Loading Process. Langmuir 2021, 37, 4, 1365–1371.

9. Novoselova M.V., German S.V., Abakumova T.O., Perevoschikov S.V., Sergeeva O.V., Nesterchuk M.V., Efimova O.I., Petrov K.S., Chernyshev V.S., Zatsepin T.S., Gorin D.A. Multifunctional nanostructured drug delivery carriers for cancer therapy: multimodal imaging and ultrasound induced drug release. Colloids and Surfaces B 2021, 200, 111576